Compatible with ALL types and brands of antifreeze including conventional green or blue (Silicate-Based) and extended life red/orange or yellow (OAT/HOAT) coolant. Also works in systems containing only water. When used in water alone, it is also recommended to use a cooling system anti-rust and water pump lube. Protects the entire cooling system. Will not damage cooling system and is non-toxic. Tablets fully dissolve in minutes. Harmless to ALL plastic, metals, aluminum, hoses and connections.